Topical products like Avexia's 1:1 Harmony Lotion, which are applied to the skin, are designed primarily for localized relief of pain, inflammation, and other skin-related issues. The cannabinoids in topicals, such as THC and CBD, interact with cannabinoid receptors in the skin but don't enter the bloodstream in significant amounts. As a result, they typically don't produce the psychoactive effects or the "high" associated with ingesting or inhaling cannabis.